刘建成

刘建成，博士，先后于生命科学学院生物技术专业（本科）、中国科学院遗传与发育生物学研究所遗传学专业（硕士）及发育生物学专业（博士）学习；博士毕业后于美国希望之城贝克曼研究所（Beckman Research Institute of City of Hope）进行博士后研究，后晋升为研究员（Staff Scientist），2023年回工作。研究方向为大脑皮质发育及神经干细胞分化调控，研究成果发表在Development、Cerebral Cortex、Cell Reports、Science Advances、Nature Communications等顶级学术期刊。

神经干细胞分化的表观遗传调控；

神经胶质细胞的早期分化及调控；

神经损伤及修复再生。

代表性论文： 

1. Jiancheng Liu, Xiwei Wu, Qiang Lu. Molecular Divergence of Mammalian Astrocyte Progenitor Cells at Early Gliogenesis. Development. 2022 Mar 1;149(5):dev199985.

2. Jiancheng Liu, Anqi Geng, Xiwei Wu, Ren-Jang Lin, Qiang Lu. Alternative RNA Splicing Associated with Mammalian Neuronal Differentiation. Cerebral Cortex. 2018 Aug1;28(8):2810-2816.

3. JianchengLiu, Xiwei Wu, Heying Zhang, Gerd P Pfeifer, Qiang Lu. Dynamics of RNA Polymerase IIPausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development. Cell Reports.2017 Aug 8;20(6):1307-1318.

4. JianchengLiu, Xiwei Wu, Heying Zhang, Runxiang Qiu, Kazuaki Yoshikawa, Qiang Lu. Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters. Developmental Neurobiology.2016 Jun;76(6):587-99.

5. RunxiangQiu, Anqi Geng, Jiancheng Liu, C Wilson Xu, Manoj B Menon,Matthias Gaestel, Qiang Lu. SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development. Cerebral Cortex. 2020 May14;30(5):3030-3043.

6. Maria AHahn, Seung-Gi Jin, Arthur X Li, Jiancheng Liu, Zhijun Huang, Xiwei Wu, Byung-Wook Kim, Jennifer Johnson, Adrienne-Denise V Bilbao, Shu Tao, Jacob A Yim, Yuman Fong, Sandra Goebbels, Markus H Schwab, Qiang Lu, Gerd PPfeifer. Reprogramming of DNA methylation at NEUROD2- bound sequences during cortical neuron differentiation. Science Advances. 2019 Oct23;5(10):eaax0080.

7. Anqi Geng, Runxiang Qiu, Kiyohito Murai, Jiancheng Liu, Xiwei Wu, Heying Zhang, Henry Farhoodi, Nam Duong, Meisheng Jiang, Jiing-Kuan Yee, WalterTsark, Qiang Lu. KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development. Nature Communications. 2018 Jul13;9(1):2707.

8. Lu Yang, Jiancheng Liu,Qiang Lu, Arthur D Riggs, Xiwei Wu. SAIC: an iterative clustering approach for analysis of single cell RNA-seq data. BMC Genomics. 2017 Oct3;18(Suppl 6):689.

9. Seung-GiJin, Zhi-Min Zhang, Thomas L Dunwell, Matthew R Harter, Xiwei Wu, Jennifer Johnson, Zheng Li, Jiancheng Liu, Piroska E Szabó, Qiang Lu, Guo-Liang Xu, Jikui Song, Gerd P Pfeifer. Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration. Cell Reports. 2016 Jan 26;14(3):493-505.

10. Fang Chen, Wei Zhang, Yu Liang, Jialiang Huang, Kui Li, Christopher D Green, Jiancheng Liu, Guojie Zhang, Bing Zhou, Xin Yi, Wei Wang, Hang Liu, Xiaohong Xu, Feng Shen, Ning Qu, Yading Wang, Guoyi Gao, A San, Luo Sang Jiang Bai, Hua Sang, Xiangdong Fang, Karsten Kristiansen, Huanming Yang, Jun Wang, Jing-Dong J Han, Jian Wang. Transcriptome and Network Changes in Climbers at Extreme Altitudes. PLoS One. 2012;7(2):e31645.

11. Chunyu Jin, Jing Li, Christopher D Green, Xiaoming Yu, Xia Tang, Dali Han, Bo Xian,Dan Wang, Xinxin Huang, Xiongwen Cao, Zheng Yan, Lei Hou, Jiancheng Liu, Nicholas Shukeir, Philipp Khaitovich, Charlie D Chen, Hong Zhang, Thomas Jenuwein, Jing-Dong J Han. Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway. Cell Metabolism. 2011 Aug3;14(2):161-72.

12. Jiancheng Liu, Like Liu, Ning Hou, Aimin Zhang, Chunguang Liu. Genetic Diversity of Wheat Gene Pool of Recurrent Selection Assessed by Microsatellite Markers and Morphological Traits. Euphytica. 2006 Dec 21;155: 249-258.

13. Chunguang Liu, Ning Hou, Like Liu, Jiancheng Liu, Xusheng Kang and Aimin Zhang. A YA-type cytoplasmic male-sterile source in common wheat. Plant Breeding.2006 Sep12;125, 437-440.