常翠芳

  常翠芳，1982年2月生，毕业于新疆大学，博士、副教授，硕士生导师。2011年博士毕业后就职于生命科学学院，主要从事细胞生物学和分子生物学的教学和科研工作。自工作以来，主持国家自然科学基金项目、河南省自然科学基金项目、教育厅项目、校级项目等，并参与完成多项国家级重大项目，在J Cell Physiol、Cell Biochem Funct等期刊发表论文50多篇，参编的《大鼠肝再生的功能基因组学研究》专著获2010年教育部自然科学二等奖。

肝纤维化、肝再生的分子调控机理

中国细胞生物学学会会员

河南省实验动物学学会理事

1.国家自然科学基金项目：丝氨酸蛋白酶抑制剂III对大鼠再生肝的肝细胞增殖调控机理研究，主持

2.河南省自然科学基金项目：丝氨酸蛋白酶抑制剂I和III调控再生肝的肝细胞机理研究，主持

3.河南省自然科学基金项目：肝再生相关孤儿受体GPR50调控肝细胞增殖的蛋白组学及其作用机制研究，主持

4.河南省高等学校重点科研项目：SPINK1 调控大鼠正常肝细胞和肝癌细胞增殖机理的比较研究，主持

5.河南省高等学校重点科研项目：干扰SPINK1对肝纤维化的影响及调控机制研究，主持

6.国家自然科学基金项目：一个大鼠肝再生相关的新lncRNA（rLALR1）调节肝细胞增殖的作用及机理研究，参与

7.国家973计划前期研究专项：大鼠肝再生的蛋白质学研究，参与

8.国家973计划前期研究专项：肝脏损伤修复与再生机制的蛋白质组学基础研究，参与

代表性论文： 

1. Chang CF, Wang DL,Xi LL, Guo XQ, Wang G,P Yu GY. The orphan GPR50 receptor interacting with TβRIinduces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells. BiochemPharmacol. 2022, 202:115117.

2.Chang CF, Xie JJ, Yang QD, Yang J, Luo YR, Xi LL, Guo JL, Yang GG, Jin W, Wang GP. Serine peptidase inhibitor Kazal type III (SPINK3) promotes BRL‐3A cell proliferation by targeting the PI3K–AKT signaling pathway. Journal of Cellular Physiology. 2020, 235(3): 2209-2219.

3.Li  JJ, Ye CL, Chang CF. Comparative  transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq. BMC  Plant Biol. 2020, 20(1):341.

4.Wang  GP, Chu PP, Chen M, Cheng LY, Zhao CC, Chen SS, Li XF, Yang GG, Chang CF. Osteopontin promotes rat  hepatocyte proliferation both in vitro and in vivo. Artificial Cells, Nanomedicine and Biotechnology. 2019, 47(1): 3745-3757.

5.Wang GP; Guo XQ, Cheng LY, Chu PP, Chen M, Chen YH, Chang CF. An integrated analysis of the circRNA-miRNA-mRNA  network reveals novel insights into pot ential mechanisms of cell proliferation during liver regeneration, Artificial Cells, Nanomedicine and  Biotechnology. 2019, 47(1): 3873-3884.

6.Chang CF, Zhao WM, Luo YR, Xi LL, Chen SS, Zhao CC, Wang GP, Guo JL, Xu CS. Serine peptidase inhibitor Kazal type I (SPINK1) promotes BRL-3A cell proliferation via p38, ERK,and JNK pathways. Cell Biochem Funct. 2017, 35(6):339-348.

7.Chang CF, Niu ZP, Gu NN,  Zhao WM, Wang GP, Jia YF, Li DM, Xu CS. Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level. BMC Cell Biology, 2015, 16:25.

8.Chang CF, Xu CS. Transcriptome atlas of aromatic amino acid family metabolism-related genes in eight liver cell types uncovers the corresponding metabolic pathways in rat liver regeneration. Int J Biochem Cell Biol, 2010, 42(10):1708-1716.

9.Xu CS, Chang CF. Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration. Amino Acids. 2008, 34(1):91-102.

10.Chang CF, Yang J, Li XF, Zhao WM, Li Y, Guo PJ, Wang GP, Xu CS. Thrombopoietin signaling pathway regulates the hepatocytes activation in rat liver regeneration. Biochem  Genet, 2015, 53(9-10): 244-259.

11.Chang CF, Yang J, Li XF, Zhao WM, Chen SS, Wang GP, Xu CS. SPINK3: A novel growth factor that promotes rat liver regeneration. Molecular Biology, 2016, 50(3):398-404.

12.Chang CF, Zhao WM, Yang J, Li MH, Zhou Y, Xu CS. Study on activity of the signaling pathways regulating hepatocyte differentiation during rat liver regeneration. Anim Cells Syst, 2014, 18(6): 416-424.

13.Chang CF, Xu CS. Transcriptome atlas of glutamine family amino acid metabolism-related genes in eight regenerating liver cell types. Cell Biol Int, 2010, 34(12):1189-1198.

14.Chang CF, Fan JY, Zhang FC, Ma J, Xu CS. Transcriptome atlas of eight liver cell types uncovers effects of histidine catabolites on rat liver regeneration. J Genet, 2010, 89(4):425-436.

15.Chang CF, Yang J, Zhao WM, Li Y, Guo PJ, Li MH, Zhou Y, Xu CS. Gene expression profiling analysis of  5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells. Genet Mol Res, 2015, 14(2): 3409-3420.

16.Chang CF, Zhao WM, Mei JX, Zhou Y, Pan CY, Xu TT, Xu CS. Branches of NF-κb signaling pathway regulate  hepatocyte proliferation in rat liver regeneration. Genet Mol Res, 2015,14 (3):7643-7654.

17.Geng XF, Chang CF, Zang XY, Sun JY, Li PF, Guo JL, Xu CS. Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration. Gene, 2016, 575(2 Pt 1):224-232.

18.Ding Y, Chang CF, Niu ZP, Dai KQ, Geng  XF, Li DM, Guo JL, Xu CS. Overexpression of Transcription Factor Foxa2 and Hnf1α induced Rat Bone Mesenchymal Stem Cells into Hepatocyte. Cytotechnology, 2016, 68(5):2037-2047.

专利成果： 

1.基于OPN基因诱导的肝细胞体外增殖方法（专利号: ZL201510773582.1）

2.一种表达人血清白蛋白的质粒和重组菌以及它们的应用(ZL 201310078906.0)

3.表达人血清白蛋白的质粒和重组菌以及它们的应用(ZL 201310078280.3)

4 一种抗癌药物及其应用（ZL 2018 10968867.4）