王兰

王兰，女，教授，博士生导师。国家肺纤维化生物学过程及防控学科创新引智基地（111计划）秘书，河南省器官纤维化杰出外籍科学家工作室负责人，中国生物物理学会表型组分会委员，河南省生物化学与分子生物学学会副理事长，河南省药学会中药资源委员会委员，河南省药学会天然产物委员会委员，国际期刊《Fibrosis》副主编。主要从事肺纤维化生物标志物和甲状腺激素调控肺纤维化的代谢稳态研究。

2011年6月博士毕业于韩国江原大学医生命学院，获得生物医学博士学位。2006.10－2007.10间，作为访问学者到丹麦哥本哈根大学生命科学学院合作研究，2016.7－2017.7 在美国华盛顿州立大学药学院访问学者，主要从事端粒酶基因的表观遗传调控研究, 2017.12--2019.08，复旦大学生科院访问研究，主要从事多组学解析疾病机理研究。目前主持及参与国家重点研发专项、国家自然基金、河南省重点研发专项、河南省国际科技合作项目、国家虚拟仿真实验教学一流课程、河南省优质资源课-双语教学示范课等项目10余项，在Am J Respir Crit Care Med 、Molecular & CellularProteomics等国际期刊发表学术论文40余篇，发明授权国家专利2项，受理3项，主编《肺纤维化小鼠模型构建，诊断及治疗》、参编《生物化学》等教材6部。

多组学解析疾病机理

肺纤维化生物标志物

甲状腺激素调控肺纤维化的代谢稳态

河南省生物化学与分子生物学学会副理事长

国际期刊《Fibrosis》副主编

中国生物物理学会表型组分会委员

河南省药学会中药资源委员会委员

河南省药学会天然产物委员会委员

1、甲状腺激素对肺纤维化的治疗作用与机理研究。国家重点研发计划任务负责人

2、基于S蛋白受体结合结构域（RBD）的新冠肺炎病毒疫苗研发及肺纤维化控制。高端外国专家引进计划新冠肺炎防控专项计划

3、肺纤维化治疗新药研发。河南省重点研发计划。第一参与人

4、肺纤维化新药GC-1研发。新乡市重大科技创新专项。第一参与人

5、器官纤维化杰出外籍科学家工作室。河南省外国专家项目。负责人

6、特发性肺纤维化诊断血清标志物的确立。河南省科技攻关项目，主持

7、多组学解析甲状腺激素调控肺纤维化的机制。河南省国际科技合作，主持

8、肺纤维化血清标志物的研发。横向合作。主持

9、植物源性抗菌肽生物活性研究。河南省重点科技攻关项目。主持

10、火炬树果实有效成分抑制结肠癌机理研究。河南省科技攻关项目。主持

11、肺纤维化小鼠模型构建、诊断及治疗虚拟仿真实验。国家级一流课程

12、《高级生物化学》河南省优质资源课双语教学示范课，负责人

代表性论文：

1.Lan Wang;Minghui Zhu; Yan Li; Peishuo Yan; Zhongzheng Li; Xiuping Chen; Juntang Yang;Xin Pan; Huabin Zhao; Shenghui Wang; Hongmei Yuan; Mengxia Zhao; Xiaogang Sun;Ruyan Wan; Fei Li; Xiaobo Wang; Hongtao Yu; Ivan Rosas; Chen Ding; Guoying Yu*.Serum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis, Molecular & Cellular Proteomics, 2023

2.Lan Wang, Hongmei Yuan, Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li,Huabin Zhao, Shenghui Wang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan,Ivan Rosas, Guoying Yu*. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.BBA - Molecular Basis of Disease 1870(2024) 166960

3.Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, YaxuanWang, Lianhui Cheng, Huibing Liu, Juntang Yang, Yajun Li, Ivan Rosas,Guoying Yu*. TRIOBP modulates β‑cateninsignaling by regulation of miR‑29b in idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences (2024)81:13.

4.Lan Wang;Zhongzheng Li; Ruyan Wan; Xin Pan; Bin Li; Huabin Zhao; Juntang Yang; Weiming Zhao; Shenghui Wang; Qiwen Wang; Peishuo Yan; Chi Ma; Hongmei Yuan; Ivan Rosas;Chen Ding; Baofa Sun; Guoying Yu*. Single-cell RNA-seq provides new insights into therapeutic roles of thyroid hormone in the idiopathic pulmonary fibrosis,Am J Respir Cell Mol Biol, 2023 Oct;69(4):456-469.

5. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang,Juntang Yang, Yajun Li, Ivan Rosas,Lan Wang* and Guoying Yu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Respiratory Research (2023) 24:318.https://doi.org/10.1186/s12931-023-02633

6.Ruyan Wan,Lan Wang, Miaomiao Zhu, Wenwen Li,Yudi Duan and Guoying Yu*. Cellular Senescence: A Troy Horse in Pulmonary Fibrosis. Int. J. Mol. Sci. 2023, 24(22), 16410.

7.Ruyan Wan,Lan Wang, Yudi Duan, Miaomiao Zhu,Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu*. ADRB2 inhibition combined with antioxidant treatment alleviates lungfibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts. Cell Death Discovery

8.Zhao H, Wang J, Li Z, Wang S, Yu G andWang Lan*.Identification ferroptosis-related hub genes and diagnostic model inAlzheimer’s disease. Frontiers in Molecular Neuroscience. 16:1280639.

9.Weiming Zhao;Lan Wang; Juntang Yang; Xinyu Chen; Xiaoshu Guo; Kai Xu; Ningdan Wang; Wenyu Zhao; Cong Xia; Hui Lian; Ivan Rosas; Guoying Yu ; Endothelial cell-derived MMP19 promotes pulmonary fibrosisby inducing E(nd)MT and monocyte infiltration, Cell Communication and Signaling, 2023, 21(56): 1-17

10.Weiming Zhao;Lan Wang; Yaxuan Wang; Hongmei Yuan; Mengxia Zhao; Hui Lian; Shuaichen Ma; Kai Xu; Zhongzheng Li; Guoying Yu*. Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis, International Journal of Molecular Sciences, 2023, 24(10):8749-8766.

11.Zhongzheng Li, Liu Xin,Lan Wang, Huabin Zhao, ShenghuiWang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han. Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia. Front.Immunol. Volume 14 - 2023.

12. Zhongzheng Li; Shenghui Wang; Huabin Zhao; Peishuo Yan; Hongmei Yuan;Mengxia Zhao; Ruyan Wan; Guoying Yu;Lan Wang*. Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports, 2023,13(1): 1-15

13. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li,Ivan Rosas,Lan Wang* and Guoying Yu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly.Respiratory Research (2023) 24:318.

14.Lan Wang; Wenyu Zhao; Cong Xia; Zhongzheng Li;Weiming Zhao; Kai Xu; Ningdan Wang; Hui Lian; Ivan O. Rosas; Guoying Yu ; TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 inIPF, Int. J. Mol. Sci., 2022, 23(24):15705

15.Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan, Weiming Zhao,Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas and Guoying Yu*. Fenbendazole attenuates bleomycin-Induced pulmonary fibrosis in mice via suppression of fibroblast-to-myofibroblast differentiation. Int. J. Mol. Sci. 2022,23,14088.

16.Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu*. Inhibition of MAD2L1 mediates pulmonary fibrosis through impairment of mitochondrial function and induction of cell senescence. Canadian Respiratory Journal, 2022, Article ID 9663354, 13

17. Juntang Yang; Chenxi Liang; Lulu Liu;Lan Wang; Guoying Yu ;High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters, Biomolecules,2023

18.Wang Y, Gong W,Zhou H, Hu Y,Wang L, Shen Y, Yu Guoying, Cao J. A novel miRNA from egg-derived exosomes of Schistosoma japonicum promotes liver fibrosis in murine schistosomiasis. Front. Immunol., 27 April 2022

19.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. Thyroid Hormone Signal Attenuates Pulmonary Fibrosis Through Cell Interaction and Communication in Bleomycin-Induced Mouse Lung. Am J Respir Crit Care Med 2022;205:A1963

20.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. A weighted gene co-expression network analysis (WGCNA)identifies the key genes associated with IPF. Am J Respir CritCare Med 2021;203: A4641

21.Yang J, Pan X,Wang L, Yu Guoying*.Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis. Molecular medicine 2020, 26(1).

22.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. Serum proteome profiling discovers novel proteinsassociated with idiopathic pulmonary fibrosis. Am J Respir Crit CareMed 2020;201: A4021

23.Lan Wang，Ming Lu Xu，Ling Xin，Chi Ma，Guoying Yu. Oxidative stress inducedapoptosis mediated anticancer activity ofRhus typhinafruits extract inhuman colon cancer. Medicinal Chemistry Research, 2019, (28), 6, 917–925

24.Lan Wang, Ming Lu Xu, Jie Liu , You Wang ,Jian He Hu, Myeong-Hyeon Wang.Sonchus asperextract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages. Nutrition Research and Practice，2015;9(6):579-585

25. Yong-Chao Li,Lan Wang, Ben-zhai Hai and Ming-Lu Xu. Effect of Various Treatment Methods on the Bisphenol A Concentration in Edible Mushroom Segments during Cultivation.Advance Journal of Food Science and Technology 13(1): 40-48, 2017

26.Lan Wang, Ming Lu Xu, Jian He Hu, Søren K.Rasmussen, Myeong-Hyeon Wang.Codonopsis lanceolataextract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells - Involvement of ROS generation and polyamine depletion. Food and Chemical Toxicology 2011, 49:149-154.

27.Lan Wang, MingLu Xu, Li Jie Guo , Lin Song Wang. Antioxidant activities and phenolic compounds of various extracts ofRhus typhinafruits and leaves.Advance Journal of Food Science and Technology 2015 ,7(4): 223-229.

28.Lan Wang, Hee Jeong Son, Ming-Lu Xu, Jian-He Hu, and Myeong-Hyeon Wang*. Anti-inflammatory and anticancer properties of dichloromethane and butanol fractions from the stem bark ofBroussonetia papyrifera. Journal Korean Social Application Biology Chemistry 2010, 53(3):297-303.

29.Lan Wang, Ming Lu Xu, Søren K. Rasmussen ,Myeong-Hyeon Wang*. Vomifoliol 9-O-α-arabinofuranosyl (1→6)-β-D-glucopyranoside from the leaves ofDiospyros Kakistimulates the glucose uptake in HepG2 and 3T3-L1 cells. Carbohydrate Research. 2011,346:1212-1216.

30.Lan Wang, Gui-Fang Xu, Xiao-Xia Liu, Ai-Xia Chang, Ming-Lu Xu, Amal Kumar Ghimeray, Jing-Pei Piao and DongHa Cho*. In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction fromLiriodendron tulipifera. Journal of Medicinal Plants Research 2012, 6(3):424-432.

31. Ming-Lu Xu，Lan Wang, Gui-Fang Xu, Jian-He Hu, and Myeong-Hyeon Wang*. Antioxidant and anti-proliferative activities of different solvent fractions from methanol extracts ofSparganiun stoloniferum. Horticulture Environment and Biotechnology. 2010, 51(6):539-544.

32. Li Wang,Lan Wang, Fang-Jun Li, Lin-Song Wang*, and Myeong-Hyeon Wang Modulation of endogenous peroxidase by exogenous peroxidase in chinese red radish seedling. Hort. Environ. Biotechnol.2011, 52(5):448-454.

33. HuanLiu,Lan Wang,and Myeong-Hyeon Wang*. Antioxidant and nitricoxide release inhibition activities of methanolic extract from Many flower Glorybower.Horticulture, Environment, and Biotechnology. 2011, 52(3):1-6.

34. Ming-Lu Xu,Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities and related polyphenolic constituents of the methanol extract fractions fromBroussonetia papyriferastem bark and wood. Food Sci. Biotechnol.2010, 19(3):677-682.

35. Xiao Xia Liu*,Lan Wang, Yu Jie Wang, Li Ling Cai.D-glucose Enhanced 5-Aminolevulinic Acid Production in Recombinant Escherichia coli Culture. 2010, 160:822-830.

36. Ming-Lu Xu,Lan Wang, Jian-He Hu, Soek Ki Lee, andMyeong-Hyeon Wang*. Antioxidant activities and related polyphenolicconstituents of the methanol extract fractions fromBroussonetia papyriferastem bark and wood.Food Sci. Biothechnol. 2010, 19(3): 677-682.

37. Ming-Lu Xu,Lan Wangand Myeong-Hyeon Wang*. TheAntioxidant and Anticancer Effects of MeOH Extract ofLiriodendron tulipifera. Korean J. Plant Res. 2011, 24(1):23-29.

38. Ming-Lu Xu,Lan Wang, Gui-Fang Xu and Myeong-Hyeon Wang*.Antidiabetes and Angiotensin Converting Enzyme Inhibitory Activity ofSonchus asper(L) Hill Extract. Kor. J. Pharmacogn. 2011, 42(1):61-67.

39. 朱明慧，万汝燕，李飞，王晓博，于洪涛，王兰，余国营。特发性肺纤维化血清生物指示物的研究。国际呼吸杂志，2020年12月第40卷第23期，1801-05

40. 邢双涛，冯世杰，张一凡，王兰，余国营。不同运动方式对哮喘患儿肺功能影响的网状Meta分析.[J].学报(自然科学版),2023（02）

发明专利：

1.王兰;余国营。特发性肺纤维化疾病血液诊断标志物 CBRI 及其在制备诊断或预后工具中的应用, 2020-11-05, 中国, 202011218094.1 (专利)

2.王兰;闫培硕; 余国营。特发性肺纤维化疾病诊断标志物 CCT6A 及其制备诊断或预后工具中的应用,2020-11-5, 中国, 202011218095.6 (专利)

3.王兰; 余国营。特发性肺纤维化疾病诊断标志物及其制备诊断或预后工具中的应用, 2019-12-13, 中国, 201911277110.1 (专利)

4.王兰，邱宗波，许明录，常爱霞，周春娥, 李建军。一种从火炬树果实中提取木犀草素和木犀草素-7-O-β-D-吡喃葡萄糖苷的方法（ZL201510050991.9），国家发明专利，2017

5.胡建和，杭柏林，王青，付登峰，许明录，王兰，尚田田，徐彦召，刘兴友。抗菌肽NX-16及其制备方法和利用（ZL201110168592.4）,国家发明专利，2013

著作：

1.《肺纤维化小鼠模型构建、诊断及治疗》数字化教材，高等教育出版社，主编，2022

2.《动物源性抗菌肽》，科学出版社，副主编，2015年

3.《基因工程》，科学出版社，参编，2012年

4.《生物化学》，科学出版社，参编，2011，2016年

5.《生物化学习题集》，科学出版社，参编，2012年