李亚军

liyajun@htu.edu.cn

   李亚军，博士，讲师。2021年6月获武汉大学细胞生物学博士学位，期间从事E3泛素连接酶调控结直肠癌进展的研究，2021年7月就职于生命科学学院。参与3项国家自然科学基金项目的研究工作，以第一作者在CellDeath and Differentiation SCI期刊上发表论文1篇。主要从事E3泛素连接酶调控肺纤维化发展的研究。

Li Yajun, PhD, lecturer，obtained ph. D. degree in cell biology from Wuhan University in June2021, worked on the regulation of E3 ubiquitin ligase in the progression of colorectal cancer. In July 2021, he worked at the School of Life Sciences,Henan Normal University. Participated in three research projects of National Natural Science Foundation of China, and published one paper in Cell Death and Differentiation as the first author. Mainly engaged in the study of E3 ubiquitin ligase regulation of pulmonary fibrosis development. 

E3泛素连接酶在肺纤维化发展中的作用以及其作为治疗靶标的潜能。

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1、国家自然科学基金委员会, 重大研究计划, 92057108, USP19-ME1轴在脂质代谢重塑和结直肠癌变中的作用及调控机制,2021-01-01 至 2023-12-31, 79万元, 在研, 参与

2、国家自然科学基金委员会, 青年科学基金项目, 81802782, 肠道微生物厚壁菌促进结直肠细胞癌变的分子机制研究,2019-01-01 至 2021-12-31, 21万元, 结题, 参与  

3、国家自然科学基金委员会, 面上项目, 81772609, 小鼠中microRNA-148a缺失改变肠道菌群平衡和加剧结直肠癌变的分子机制研究,2018-01-01 至 2021-12-31, 60万元, 结题, 参与

代表性论文：

1.Yajun Li; Kaisa Cui; Qiang Zhang; Xu Li; Xingrong Lin; Yi Tang; Edward VProchownik; Youj

unLi ; FBXL6 degrades phosphorylated p53 to promote tumor growth., Cell Death and Differentiation, 2021, 16(3): 2112-2125 (IF15.828/Q1)

2.Li Gu; Yahui Zhu; Xi Lin; Yajun Li; Kaisa Cui; Edward V. Prochownik; Youjun Li; Amplific

ationof glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1to promote hepatocarcinogenesis., Cancer Research, 2018, 78(20): 5808-5819 (IF 12.701 /Q1)

(3)Zhu, Yahui; Gu, Li; Li, Yajun; Lin, Xi; Shen, Hongxing; Cui, Kaisa; Chen, Li; Zhou,Feng;

Zhang,Jinxiang; Zhong, Bo; Prochownik, Edward; Li, Youjun; Zhao, Qiu ; miR-148a inhibits colitis and colitis-associated tumorigenesis in mice, Cell Death and Differentiation, 2017, 12(24): 2199-2209(IF15.828/Q1)