孔祥会 博士 教授 博导
孔祥会，博士，二级教授，博士生导师。水产动物疾病控制河南省工程实验室主任，河南省学术技术带头人，河南省科技创新杰出青年，河南省高校创新人才，水产一级学科带头人，水产博士学位授权点带头人，河南省创新型科技团队带头人。获河南省先进工作者，河南省优秀党员，河南省职业道德建设先进个人，首届校园十大育人楷模等称号。现为中国水产学会理事，中国鱼类学会理事，河南省水产学会秘书长。2004年获厦门大学博士学位；2007年中科院水生所生物学博士后流动站完成博士后研究；2009-2010年在美国University of California, Los Angeles (UCLA)留学。
孔祥会教授长期以来从事水产动物免疫和疾病防控、免疫组学解析、疫苗研发和药物创新等研究，并取得重要研究成果。主持国家自然科学基金3项,主持国家863项目子课题、河南省科技创新杰出青年计划和河南省重点科技攻关项目等20余项；参与完成国家自然科学基金重点项目、国家973项目子课题、国家“蓝色粮仓”重点专项等。在Aquaculture, Vaccine, Fish Shellfish Immun, J Fish Dis，中国科学和科学通报等重要学术刊物上发表学术论文160余篇，其中SCI源期刊收录论文80余篇。出版学术专著3部，授权国家发明专利5项，获河南省科技奖励3项。
▊已取得的创新性成果
孔祥会教授创新性成果及科学发现主要有：（1）采用分子免疫学、免疫组学和生物信息学等技术方法，系统研究了病原感染后水产动物免疫响应模式、信号调控通路及其免疫调节机制。学术成果发表在Aquaculture、Fish & Shellfish Immunology等期刊发表。此外，还分别研究了抗菌肽、抗氧化酶、溶菌酶等不同的天然免疫相关基因及其对病原体的响应。（2）系统研究了水产动物重要病原的生物学和流行病学，弄清病原与机体互作、入侵致病过程及其致病机制，为疾病防控提供指导。取得的重要学术成果已在Aquaculture、Journal of fish disease等期刊发表上发表。（3）水产动物疫苗研发和疫苗导入技术。针对重要致病病原，研究和制备高效的灭活疫苗、弱毒疫苗和亚单位疫苗。取得的重要成果已在Vaccine、Fish & Shellfish Immunology等期刊发表；团队自行研发的超声波和高渗食盐辅助浸浴法高效疫苗导入技术，对小规格鱼种免疫有独到优势，已推广应用2000余亩，获得较好的经济效益和生态效益。（4）新型绿色渔药创制。利用代谢组学筛选水产动物小分子代谢物，作为渔药增效剂，以大幅减量渔药使用。研发适用于水产动物的中草药制剂和免疫增加剂，以增强机体免疫，预防疾病的发生。
▊代表性科研项目
（1）主持国家自然科学基金联合基金项目（U2004154），项目名称：嗜水气单胞菌感染后黄河鲤IL-1β生成和分泌调控的分子机制研究，在研，项目执行期：2021-2023。
（2）主持国家自然科学基金联合基金项目(U1604104)，项目名称：草鱼pIgR受体结合和转运IgM的分子机制研究，结项。
（3）主持国家自然科学基金项目(30770299)，项目名称:尺寸控制基因调控序列在鲤科鱼类中的变异及系统演化，结项。
（4）主持河南省科技创新杰出青年计划(124100510017)，项目名称：鱼类组蛋白H2B衍生抗菌肽基因变异对抗菌影响及高活性抗菌肽筛选，结项。
（5）主持河南省高校科技创新团队支持计划（15IRTSTHN018），团队名称：水产动物医学，结项。
（6）主持河南省高校科技创新人才支持计划(2011HASTIT012)，项目名称：鱼类低氧诱导因子HIF-1α分子进化和基因改造及作用研究，结项。
▊代表性学术论文
孔祥会近5年以第一作者或通讯作者发表的代表性论文：
【1】Yuan Gaoliang#, Zhu Lei#, Jiang Xinyu, Zhang Jie, Pei Chao, Zhao Xianliang, Li Li,Kong Xianghui*. Diagnosis of co-infection with white spot syndrome virus andAeromonas veroniiin red swamp crayfishProcambarus clarkia.Aquaculture, 2021,532: 736010.
【2】Zhu Lei#, Yuan Gaoliang#, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li,Kong Xianghui*. Molecular characterization of Rab5 and Rab6, and their involvement in innate immunity in red swamp crayfishProcambarus clarkia.Aquaculture,2021,533: 736085.
【3】Zhu Lei, Gao Yuanyuan, Yuan Gaoliang, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li,Kong Xianghui*. Identification and immune functional analysis of a novel C1q domain-containing protein in Yellow River Carp (Cyprinus carpioL.).Aquaculture, 2021,534: 736313.
【4】Wang Li, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li,Kong Xianghui*. Molecular characterization and biological function of a tandem-repeat galectin-9 in Qihe crucian carpCarassius auratus.Fish and Shellfish Immunology, 2020,103: 366-376.
【5】Wu Limin, Li Yongjing, Xu Yufeng, Wang Lei, Ma Xiao, Dong Chuanju, Zhao Xianliang, TianXue, Li Xuejun*,Kong Xianghui*. The roles of two myostatins and immune effects after inhibition in Qi river crucian carp (Carassius auratus).Fish & Shellfish Immunology, 2020, 98: 710-719.
【6】Zhao Xian-liang, Wu Gan, Chen He, Li Li,Kong Xiang-hui*. Analysis of virulence and immunogenic factors inAeromonas hydrophila: Towards the development of live vaccines.Journal of Fish Disease, 2020,43:747-755.
【7】Zhang Jie, Zhu Yachen, Chen Zhuo, Li Chunjing, Zhao Xianliang,Kong Xianghui*.Molecular cloning and expression analysis of MyD88 and TRAF6 in Qihe crucian carpCarassius auratus.Fish and Shellfish Immunology, 2019, 87: 829-838.
【8】Gao Yan, Pei Chao, Sun Xiaoying, Zhang Chao, Li Li,Kong Xianghui*. Novel subunit vaccine based on grass carp reovirus VP35 protein provides protective immunity against grass carp hemorrhagic disease.FishandShellfish Immunology,2018, 75:91-98.
【9】Zhao Xianliang, Chen He, Jin Zhaohui, Li Li, Zhang Jie,Kong Xianghui*. GC-MS-based metabolomics analysis reveals L‐aspartate enhances the antibiotic sensitivity of neomycin sulfate-resistantAeromonas hydrophila.Journal of fish diseases, 2018, 41(12): 1831-1841.
【10】Gao Yan #, Pei Chao #, Sun Xiaoying, Zhang Chao, Li Li,Kong Xianghui*. Plasmid pcDNA3.1-s11 constructed based on the S11 segment of grass carp reovirus as DNA vaccine provides immune protection.Vaccine, 2018, 36:3613-3621.
【11】Kong Xianghui*, Wang Li, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li. Comparison of polymeric immunoglobulin receptor between fish and mammals.Veterinary Immunology and Immunopathology, 2018,202: 63-69.
【12】Zhao Xianliang, Chen He, Zhong Keke, Li Li,Kong Xianghui*. Myo-inositol as an adjuvant to florfenicol againstAeromonas hydrophilainfection in common carpCyprinus carpio.FEMS Microbiology Letters, 2018, 365(20): fny212.
【13】Zhang Jie, Wang Li, Zhao Yanjing,Kong Xianghui*, Wu Fan, Zhao Xianliang. Molecular characterization and expression analysis of toll-like receptors 5 and 22 from natural triploidCarassius auratus.Fish and Shellfish Immunology,2017,64:1-13.
【14】Kong Xianghui*,Wu Xiangmin, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li, Nie Guoxing, Li Xuejun. H2A and Ca-L-hipposin gene: Characteristic analysis and expression responses toAeromonas hydrophilainfection inCarassius aurutus.Fish and Shellfish Immunology, 2017,63: 344-352.
【15】Di Guilan, Li Hui, Zhang Chao, Zhao Yanjing, Zhou Chuanjiang, Naeem Sajid, Li Li,Kong Xianghui*. Label-free proteomic analysis of intestinal mucosa proteins in common carp (Cyprinus carpio) infected withAeromonas hydrophila.Fish and Shellfish Immunology, 2017, 66: 11-25.
【16】Wang Li, Zhang Jie,Kong Xianghui*, Zhao Xianliang, Pei Chao, Li Li. A C-type lectin, Nattectin-like protein (CaNTC) in Qihe crucian carpCarassius auratus: Binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria.Fish and Shellfish Immunology, 2017, 67: 382-392.
【17】Kong Xianghui*, Qiao Dan, Zhao Xianliang, Wang Li, Zhang Jie, Liu Dandan , Zhang Hongxu. The molecular characterizations of Cu/ZnSOD and MnSOD and its responses of mRNA expression and enzyme activity toAeromonas hydrophilaor lipopolysaccharide challenge in Qihe crucian carpCarassius auratus.Fish and Shellfish Immunology,2017, 67: 429-440.
【18】Wang Li, Zhang Jie,Kong Xianghui*, Pei Chao, Zhao Xianliang, Li Li. Molecular characterization of polymeric immunoglobulin receptor and expression response toAeromonas hydrophilachallenge inCarassius auratus.Fish and Shellfish Immunology, 2017, 70: 372-380.
【19】Zhao Yanjing, Jiang Xinyu,Kong Xianghui*,Di Guilan, Nie Guoxing，Li Xuejun. Effects of hypoxia on lysozyme activity and antioxidant defences in the kidney and spleen ofCarassius auratus.Aquaculture Research, 2017, 48: 223-235.
【20】Wang Meijuan, Zhao Xianliang,Kong Xianghui*, Wang Li, Jiao Dan, Zhang Hongxu. Molecular characterization and expressing analysis of the c-type and g-type lysozymes in Qihe crucian carpCarassius auratus.FishandShellfish Immunology, 2016, 52: 210-220.
【21】Jiang Xinyu, Zhang Chao, Zhao Yanjing,Kong Xianghui*,Pei Chao, Li Li, Nie Guoxing, Li Xuejun. Immune effects of the vaccine for live attenuatedAeromonas hydrophilascreened using rifampicin on common carp (Cyprinus carpioL.).Vaccine, 2016, 34(27):3087-3092.
【22】Zhang Jie, Chen Zhuo, Zhou Chuanjiang,Kong Xianghui*. Molecular phylogeny of the subfamily Schizothoracinae (Teleostei: Cypriniformes: Cyprinidae) inferred from complete mitochondrial genomes.Biochemical Systematics and Ecology, 2016,64: 6-13.
【23】Jiang Hongxia,Kong Xianghui*, Wang Shuping, Guo Huiyun. Effect of copper on growth, digestive and antioxidant enzyme activities of juvenile Qihe crucian carp during exposure and recovery.Bulletin of Environmental Contamination and Toxicology,2016, 96:333-340.
【24】赵燕静，狄桂兰，孔祥会*，张杰，李莉，聂国兴，李学军.低氧环境下poly I:C刺激对淇河鲫肝胰脏抗氧化防护的影响，水产学报，2016, 40: 1830-1841.
▊科研团队理念
做一流学问，树一流人品，育一流人才
▊研究生招生和博士后入站
硕士生招生：水产一级硕士点
学术型硕士：水产动物医学方向；
专业型硕士：水产动物疾病防控方向。
博士生招生：水产一级博士点
招生方向：水产动物医学（水产动物免疫和疾病防控）；
博士后入站：生物学博士后流动站常年招收博士后
▊联系方式
河南省新乡市建设路46号，水产学院，邮编：453007
电子邮件：xhkong@htu.cn；xhkong@htu.edu.cn
欢迎有志之士加盟我们的科研团队，走进科学殿堂，探索科学奥秘。
