张新迎个人简介

张新迎

博士，教授，博士生导师。

电话：0373-3329261；E-mail：xinyingzhang@htu.cn

教育与工作经历：

1987.09-1991.06 ，化学专业，理学学士

1991.09-1994.06 ，有机化学专业，理学硕士

1994.07-2004.07 ，助教、讲师、副教授

2004.08-2006.12 美国北亚利桑那大学及马里兰大学，访问学者

2007.01-2007.08 ，副教授

2007.09-2010.06 ，环境科学专业，工学博士

2010.07 至今 ，教授

主讲课程：
物理有机化学；高等有机化学；有机化学实验

研究领域与兴趣：
1. 绿色合成新方法研究
2. 新型核苷衍生物的绿色合成及生物活性研究

近年来主持的主要科研项目:

1.河南省高校科技创新团队支持计划（20IRTSTHN005）：有机功能分子的绿色合成及性能研究，2020.01-2021.12。

2.河南省高校科技创新人才支持计划（15HASTIT005）：噻吩、呋喃及吡喃并嘧啶双环核苷的绿色合成及性能研究，2015.01-2017.12。

3. 国家自然科学基金项目（21172057）：新型六元杂环并嘧啶双环核苷的设计、合成及生物活性研究，2012.01-2015.12。

4. 河南省基础与前沿技术研究项目（092300410237）：嘧啶核苷—氢化喹啉杂化体的合成及生物活性研究。

5. 河南省国际科技合作项目（094300510054）：5-取代嘧啶碳环核苷的合成及抗病毒活性研究。

6. 河南省教育厅自然科学基金项目（2009A150017）：新型核苷类似物的绿色合成及生物活性研究。

代表性论文：

35.Yuanshuang Xu, Mengyang Shen, Xinying Zhang*, and Xuesen Fan*.Selective Synthesis of Pyrazolo[1,2-a]pyrazolones and 2-Acylindoles via Rh(III)-Catalyzed Tunable Redox-Neutral Coupling of 1-Phenylpyrazolidinones with Alkynyl Cyclobutanols.Org. Lett.,2020,22, 4697-4702.

34.Linghua Zhang, Yuanshuang Xu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*.Synthesis of Pyrazolone Fused Benzodiazepines via Rh(III)-Catalyzed [4 + 3] Annulation of 1-Phenylpyrazolidinones with Propargyl Alcohols.Org. Chem. Front.,2020,7, 2284-2290.

33. Yuanshuang Xu, Linghua Zhang, Mengyang Liu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of Benzoazepine DerivativesviaRh(III)-catalyzed Inert C(sp²)-H Functionalization and [4 + 3] Annulations.Org. Biomol. Chem.,2019,17, 8706-8710.

32. Cai Gao, Bin Li, Xueyang Geng, Qianting Zhou, Xinying Zhang*, and Xuesen Fan*. Two Birds with One Stone: One-pot Simultaneous Synthesis of 2,2,2-Trifluoroethyl phenanthridines and Benzochromenones Featuring the Utilization of the Byproduct of Togni’s Reagent.Green Chem.,2019,21, 5113-5117.

31.Xi Chen, Muhua Wang, Xinying Zhang*, and Xuesen Fan*. Rh(III)-Catalyzed Cascade Reactions of Sulfoxonium Ylides with α-Diazocarbonyl Compounds: An Access to Highly Functionalized Naphthalenones.Org. Lett.,2019,21,2541-2545.

30. Qianqian Wang, Xinying Zhang*, and Xuesen Fan*.Synthesis of 2-Aminobenzophenones throughAcylation ofAnilines with α-OxocarboxylicAcidsAssisted bytert-ButylNitrite.Org. Biomol. Chem.,2018,16,7737-7747.

29.Xia Song,Cai Gao,Xinying Zhang*, and Xuesen Fan*.Synthesis of Diversely Functionalized 2H-Chromenes through Pd-Catalyzed Cascade Reactions of 1,1-Dibromoolefin Derivatives with Arylboronic Acids.J. Org. Chem.,2018,83, 15256-15267.

28.Xia Song,Cai Gao,Bin Li,Xinying Zhang*, and Xuesen Fan*.Regioselective Synthesis of 2-Alkenylindoles and 2-Alkenylindole-3-carboxylates through the Cascade Reactions ofN-Nitrosoanilines with Propargyl Alcohols.J. Org. Chem.,2018,83, 8509-8521.

27.Yuanshuang Xu, Bin Li,Xinying Zhang*, and Xuesen Fan*.One-Pot Synthesis of Fused N,O-Heterocycles through Rh(III)-Catalyzed Cascade Reactions of Aromatic/VinylicN-Alkoxyamides with 4-Hydroxy-2-alkynoates.Adv. Synth. Catal.,2018,360, 2613-2620.

26.Qianqian Wang, Zhangxin Wang,Xinying Zhang*, and Xuesen Fan*.Microwave-Promoted Metal-Free α-Alkylation of Ketones with Cycloalkanes through Cross-Coupling of C(sp3)-H Bonds.Asian J. Org. Chem.,2017,6, 1445-1450.

25.Yuanshuang Xu, Bin Li,Xinying Zhang*, and Xuesen Fan*.Metal-Free Synthesis of 2-Aminobenzothiazoles via Iodine-Catalyzed and Oxygen-Promoted Cascade Reactions of Isothiocyanatobenzenes with Amines.J. Org. Chem.,2017,82, 9637-9646.

24.Qianqian Wang, Zhangxin Wang, Yuanshuang Xu,Xinying Zhang,* and Xuesen Fan*.Bu₄NI-Catalyzed and^tBuOOH-Oxidized Esterification of Aldehydes with Alkyl Halides in Water.Asian J. Org. Chem.,2016,5, 1304-1308.

23.Shitao Duan, Yuanshuang Xu, Xinying Zhang*, and Xuesen Fan*.Synthesis of 2,2’-Biphenols through Direct C(sp²)–H Hydroxylation of [1,1’-biphenyl]-2-ols.Chem. Commun.,2016,52, 10529-10532.

22.Xinying Zhang*, Zhangxin Wang, Xuesen Fan*, and Jianji Wang.Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond.J. Org. Chem.,2015,80, 10660-10667.

21.Xinying Zhang*,Xiaojie Guo, and Xuesen Fan*.Synthesis of 2-Aminoquinoline-3-carboamides and Pyrimido[4,5-b]quinolin-4-ones through Copper-Catalyzed One-pot Multicomponent Reactions.Chem.Asian J.,2015,10, 106-111.

20.宰文静，蒋盼盼，张新迎*，Philippe M. Loiseau，郭胜海，范学森*.嘧啶核苷-查尔酮杂化体的合成及其抗利什曼原虫活性研究.有机化学,2015,35, 1335-1341.

19. Yan He, Xinying Zhang*, and Xuesen Fan*. One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones Leading to 2-Arylphenols and Dibenzopyroanones.Chem. Commun.,2014,50, 14968-14970.

18. Xinying Zhang,* Yunping Song, Lin Gao, Xiaojie Guo, and Xuesen Fan*. Highly Facile and Regio-selective Synthesis of Pyrazolo[1,5-a]pyrimidines via Reactions of 1,2-Allenic Ketones with Aminopyrazoles.Org. Biomol. Chem.,2014,12, 2099-2107.

17. Xinying Zhang*, Xiaojie Guo, Liangliang Fang, Yunping Song, and Xuesen Fan*.Copper-catalyzedN- andO-arylation of Amides: Alternative Approaches to 3,4- Dihydroquinolin-2-ones, Quinolin-2-ones, and 12H-Chromeno[2,3-b]quinolin-12-ones.Eur. J. Org. Chem.,2013, 8087-8093.

16.Yan He, Xinying Zhang*, Liangyan Cui, Jianji wang, and Xuesen Fan*.Catalyst-free Synthesis of Diversely Substituted 6H-Benzo[c]chromenes and 6H-Benzo[c]-chromen-6-ones in Aqueous Media under MWI.Green Chem.,2012,14, 3429-3435.

15.Haiyun Xu, Xinying Zhang*, Yan He, Shenghai Guo, and Xuesen Fan*.Tandem Reaction of 3-Hydroxyhexa-4,5-allenic Esters: a Novel Access to Diversely Substituted 2H-Pyran-2-ones and Indenes.Chem Commun.,2012,48, 3121-3123.

14. Xinying Zhang*, Xuefei Jia, Jianji Wang, and Xuesen Fan*. An Economically and Environmentally Sustainable Synthesis of 2-Aminobenzothiazoles and 2-Aminobenzoxazoles Promoted by Water.Green Chem.,2011,13, 413-418.

13.Xinying Zhang,* Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang, and Xuesen Fan*. Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles.Org. Lett.,2011,13, 5024-5027.

12.Xuesen Fan*, Yangyang Wang, Yingying Qu, Haiyun Xu, Yan He, Xinying Zhang*, and Jianji Wang.Tandem Reactions Leading to Bicyclic Pyrimidine Nucleosides and Benzopyran-4-ones.J. Org. Chem.,2011,76, 982-985.

11. Xinying Zhang*, Dongfang Li, Xuefei Jia, Jianji Wang, and Xuesen Fan*. CuI/[bmim]OAc in [bmim]PF₆: a Highly Efficient and Readily Recyclable Catalytic System for the Synthesis of 2,3-Disubstituted Benzo[b]furans.Catal. Commun.,2011,12, 839-843.

10. Xinying Zhang, Dongfang Li, Xuesen Fan*, Xia Wang, Xiaoyan Li, Guirong Qu*, Jianji Wang. Ionic Liquid-promoted Multi-component Reaction: Novel and Efficient Preparation of Pyrazolo[3,4-b]pyridineone, Pyrazolo[3,4-b]quinolinone and their Hybrids with Pyrimidine Nucleoside.Mol. Divers.,2010,14, 159-167.

9.Xinying Zhang, Yingying Qu, Xuesen Fan*, C. Bores, Dong Feng, Graciela Andrei, Robert Snoeck, Erik De Clercq, and Philippe M. Loiseau. Solvent-free Synthesis of Pyrimidine Nucleoside-aminophosphonate Hybrids and their Biological Activity Evaluation.Nucleosides, Nucleotides and Nucleic Acids.,2010,29, 616-627.

8.Xinying Zhang, Xiaoyan Li, Dongfang Li, Guirong Qu*, Jianji Wang, Xuesen Fan*.Ionic Liquid Mediated and Promoted Eco-friendly Preparation of Thiazolidinone and Pyrimidine Nucleoside-thiazolidinone Hybrids and Their Antiparasitic Activities.Bioorg. Med. Chem. Lett.,2009,19, 6280-6283.

7.Xinying Zhang*, Xiaoyan Li, Xuesen Fan*, Xia Wang, Jianji Wang and Guirong Qu.Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-component Reactions in Ionic Liquid.Aust. J. Chem.,2009,62, 382-388.

6. Xinying Zhang, Adel Amer, Xuesen Fan, Jan Balzarini, Johan Neyts, Erik De Clercq, Mark Prichard, Earl Kern and Paul F. Torrence*. Synthesis and Antiviral Activities of New Acyclic and “Double-Headed” Nucleoside Analogues.Bioorg. Chem.,2007,35, 221-232.

5.Xuesen Fan,Xinying Zhang,Longhu Zhou,Kathy A. Keith,Earl R. Kern,andPaul F. Torrence*.5-(Dimethoxymethyl)-2'-deoxyuridine: a Novel Gem Diether Nucleoside with Anti-orthopoxvirus activity.J. Med. Chem.,2006,49, 3377-3382.

4.Xuesen Fan,Xinying Zhang,Longhu Zhou,Kathy A. Keith,Mark N. Prichard,Earl R. Kern,andPaul F. Torrence*.Toward Orthopoxvirus Countermeasures: a Novel Heteromorphic Nucleoside of Unusual Structure.J. Med. Chem.,2006,49, 4052-4054.

3.Xuesen Fan,Xinying Zhang,Longhu Zhou,Kathy A. Keith,Earl R. Kern,andPaul F. Torrence*.Assembling a Smallpox Biodefense by Interrogating 5-Substituted Pyrimidine Nucleoside Chemical Space.Antiviral Res.,2006,71, 201-205.

2. Xinying Zhang*,Lingjun Li and Guisheng Zhang. An Efficient and Green Procedure for the Preparation ofAcylalsfrom Aldehydes Catalyzed byFe₂(SO₄)₃·xH₂O.Green Chem.,2003,5, 646-648.

1. Xinying Zhang,Xuesen Fan, Hongying Niu and Jianji Wang*.An Ionic Liquid as a Recyclable Medium for the Green Preparation of α,α’-Bis(substituted benzylidene)cycloalkanones Catalyzed by FeCl₃·6H₂O.Green Chem.,2003,5, 267-269.