白大昌

白大昌博士，副教授，硕士生导师

本科毕业于郑州大学化学系，博士毕业于中国科学院上海有机化学研究所，获2020年“Thieme Chemistry Journal Award”国际学术期刊奖，获河南省第十五届青年科技奖，并获“河南省优秀青年科技专家称号”，2020年河南省优秀青年基金，邮箱地址：baidachang@126.com; baidachang@htu.edu.cn

教育经历：

2005.09 - 2009.07:郑州大学，化学专业，理学学士

2009.09 - 2014.07:中国科学院上海有机化学研究所，有机化学专业，理学博士（硕博连读），导师：侯雪龙 研究员

工作经历：

2014.07 - 2015.08:中科院上海有机所金属有机国家重点实验室，助理研究员

2015.10–2016.10:美国内布拉斯加医学研究中心，博士后

2016.11-2020.04：，讲师

2020.04-至今：，副教授

研究兴趣和领域：

1，发展以绿色合成化学为导向的新反应方法和技术，研究过渡金属催化碳碳键活化以及手性氟化合物的合成新方法。

2，研究具有潜在生物活性分子的合成。

近年来主持的主要科研项目:

1，国家自然科学基金-青年项目，铜催化肟酯与缺电子烯烃的环加成反应，2019-2021，26万

2.河南省优秀青年科学基金，过渡金属催化不对称C-C/C-O键活化反应研，2020-2023，25万元

代表性论文：

(1).Bai, Dachang.;*Guo, Xiuli.; Wang, Xinghua.; Xu, Wenjie.; Cheng, Ruoshi. Wei, Donghui.; Lan, Yu.; Chang, Junbiao.* Umpolung reactivity of strained C–C σ-bonds without transition-metal catalysis.Nat. Commun.2024,15, 2833.

(2).Bai, Dachang.*;Wu, Fen.; Chang, Lingna.;Wang, Manman.; Wu, Hao.; Chang, Junbiao.*Highly Regio- and Enantioselective Hydrosilylation ofgem-Difluoroalkenes by Nickel Catalysis.Angew. Chem. Int. Ed.2022,61, e202114918. (Highlight bySynfacts2022, 18, 0398)

(3).Bai, Dachang.*;Yu, Yanjiang.; Guo, Haiming.; Chang, Junbiao.; Li, Xingwei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones anda,b-Unsaturated Ketones/Imines.Angew. Chem. Int. Ed.2020,59, 2740-2744. (Highlight bySynfacts2020.16.641)

(4).Bai, Dachang.; Wang, Xueli.; Zheng, Guangfan.; Li, Xingwei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates.Angew. Chem. Int. Ed.2018,57, 6633-6637.

(5). Wu, Fen.; Li, Xin.; Chang, Junbiao.;Bai, Dachang.*Palladium-catalyzed multi components oxy-aminofluorination and aminofluorination ofgem-difluoroalkenes.Chin Chem Lett.2024,35, 109155.

(6).Bai, Dachang.;*Li, Xin.; Wu. Fen.; Chang, Junbiao.* Stereoselective hydrodefluorination of CF3-substituted alkenes and gem-difluoroalkenes by H⁻.Org. Chem. Front.,2024,11, 1388–1394.

(7).Bai, Da-Chang.*;Guo, Yuanyuan.; Ma, Dandan.; Guo, Xiuli.; Wu, Hao. Copper-Catalyzed Hydroamination ofgem-Difluoroalkenes Access to Diversified α‑Difluoromethyl Amines.Org. Lett.2023,25, 533-537.

(8).Chen, Junyan.;Bai, Dachang.;^*Guo,Xiuli.; Wang, Yiyao.;Li, Xingwei.*Diastereodivergent[4+2] Annulation of Biphenylenes with EnonesviaNickel(0)-catalyzed C-C bond Activation.Chin Chem Lett.2022.33, 5056-5060.

(9).Bai, Dachang.;*Liu, Song.; Chen, Junyan.; Yu, Yanjiang.; Wang, Manman.; Chang, Junbiao.; Lan., Yu.;* Li, Xingwei.* Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis via C–C activation of diarylcyclopropenones.Org. Chem. Front.,2021,8, 3023-3031.

(10).Bai, Dachang.;* Chen, Junyan.; Zheng, Bingbing.; Li, Xueyan.; Chang, Junbiao*.Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenones via C(sp3)-O/C-C Bond Cleavage under Transition-Metal Free Conditions.Chin. J. Chem.2021,39, 2769-2773.

(11).Cui, Yixin.;Bai, Dachang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation.Chem. Commun.,2020,56, 15631-15634.

(12). Xu, Guiqing.; Chen, Qi.; Wu, Fen.;Bai, Dachang.;*Chang, Junbiao.;* Li, Xingwei.* Rh(III)-Catalyzed Chemodivergent Coupling of N‑Phenoxyacetamides and Alkylidenecyclopropanes via C−H Activation.Org. Lett.2021,23, 2927−2932.

(13). Cheng, Ruoshi.;Bai, Dachang.*Enantiodivergent Relay Coupling for Nickel-Catalyzed Stereoselective Functionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem.2021,41, 1746-1748.

(14). Cui, Yixin.;Bai, Dachang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation.Chem. Commun.,2020,56, 15631-15634.

(15). Li, Xue-yan.; Yu, Yanjiang.; Qi, Ruobing.;Bai, Dachang*.Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile.Tetrahedron Lett.2020.61, 151858-151861.

(16). Dai, Hongxue.; Wu, Fen.;Bai, Dachang*. Recent Advances in Ni-Catalyzed C-C bond Activation Reactions.Chin. J. Org. Chem.2020.40. 1423-1436.

(17).Bai, Dachang.^(#); Xia, Jintao.^(#); Song, Fangfang .; Li, Xueyan.; Liu, Bingxian.; Liu, Lihong.; Zheng, Guangfan.; Yang, Xifa.; Sun, Jiaqiong, * Li, Xingwei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp³/sp²C–H activation and 1,4-rhodium migration.Chem. Sci.2019,10. 3987-3993. (#: co-first authors)

(18) Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue,Bai Dachang.*Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates.Chin. J. Org. Chem.,2019,39, 1623-1629.

(19).Bai,Dachang.*;Xu, Teng.;Ma, Chaorui.;Zheng, Xin.;Liu, Bingxian.;Xie, Fang.;Li, Xingwei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C−H Activation: Facile Access to Bridged Cycles.ACS Catal.2018,8, 4194-4200.

(20). Yu, Feile.^(#);Bai, Dachang.^(#); Liu, Xiuyan.^(#); Jiang, Yangjie.; Ding, Changhua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers.ACS Catal.2018, 8, 3317–3321.(#: co-first authors)

(21)Bai. Dachang.;Jia, Qingqian.; Xu, Teng.; Zhang, Qiuqiu.; Wu, Fen.; Ma, Chaorui.; Liu, Bingxian.; Chang, Junbiao.; * Li, Xingwei.* Rhodium(III)-Catalyzed C–H Activation of Nitrones and Annulative Coupling with Nitroalkenes.J. Org. Chem.2017,82, 9877–9884.

(22)Bai. Dachang.;Liu, Xiu-Yan.; Li, Hao.; Ding, Changhua.;* Hou. Xue-Long.* Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity.Chem. Asian J.2017,12, 212–215.

(23)Bai, Dachang.; Yu, Feile.; Wang, Wanying.; Chen, Di.; Li, Hao.; Liu, Qingrong.; Ding, Changhua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism.Nat. Commun.2016,7,11806–11817.

(24). Wu, Hao.; Liu, Zhen.;Bai, Dachang.*¹H NMR Spectrum of Amide Compounds.Univ. Chem.2024, 39, 231.