姓名：何艳

职务：

职称：副教授

电子邮箱：heyan@htu.cn

个人简历

何艳，副教授，硕士生导师。

教育/工作经历

2020.05-至今      Betway官方客服环境学院 副教授

2016.01-2020.04  Betway官方客服环境学院 讲师

2023.09-2024.09   厦门大学化学化工学院 访问学者

2012.09-2015.12   Betway官方客服环境学院 博士

2009.09-2012.07   Betway官方客服化学化工学院 硕士

2005.09-2009.07   Betway官方客服化学化工学院 学士

研究领域

1. 以绿色合成化学为导向的新反应方法和技术研究

2. 环胺类化合物的官能团化与骨架编辑的新策略研究

主要学术及社会兼职

Chemical Communications、Organic Chemistry Frontiers、Organic Letters、Journal of Organic Chemistry、Advanced Synthesis & Catalysis 期刊审稿人

科研项目情况

[1] 国家自然科学基金-青年项目，21702050，饱和环状叔胺的C–N键氧化断裂与重组及其在官能团化环胺衍生物合成中的应用，2018-2020，25，主持

[2] 河南省重点科技攻关项目，172102310590，ddC/3TC-噻唑啉酮杂化体的绿色合成及抗HIV活性研究，2017-2018，主持

[3] 河南省高校科技创新团队支持计划，20IRTSTHN005，有机功能分子的绿色合成及性能研究，2020-2021，50万，主要参与人

代表性论文

[1]Yan He,* Qimeng Liu, Jintao Yang, Yunfei Liu, Xinying Zhang, Xuesen Fan.* Oxoammonium salt-promoted diverse functionalization of saturated cyclic amines with dinucleophiles. Chem. Commun., 2023, 59,3874-3877.

[2]Yan He,* Qimeng Liu, Tian Gong, Yunfei Liu, Xinying Zhang, Xuesen Fan.* Tunable synthesis of α,β-multifunctionalized azaheterocycles via the cascade reaction of saturated cyclic amines with diverse nucleophiles promoted by oxoammonium salt. Org. Chem. Front., 2023, 10, 1206-1212.

[3]Yan He,* Qimeng Liu, Jintao Yang, Zhi Zheng, Guo-Li Chai, Xinying Zhang, Xuesen Fan.* Oxoammonium salt-promoted multifunctionalization of saturated cyclic amines based on β-oxo cyclic iminium ion intermediates. Org. Lett., 2022, 24, 7839-7844.

[4]Yan He,* Qimeng Liu, Zihe Du, Yanhua Xu, Lingyu Cao, Xinying Zhang, Xuesen Fan.* B(C₆F₅)₃-Catalyzed α,β-difunctionalization and C−N bond cleavage of saturated amines with benzo[c]isoxazoles: access to quinoline derivatives. J. Org. Chem., 2022, 87, 14840-14845.

[5]Yan He,* Zhi Zheng, Jintao Yang, Xinying Zhang, Xuesen Fan.* Recent advances in the functionalization of saturated cyclic amines. Org. Chem. Front., 2021, 8, 4582-4606.

[6] Yan He,* Jintao Yang, Xinying Zhang, Xuesen Fan.* Selective cleavage and reconstruction of C–N/C–C bonds in saturated cyclic amines: tunable synthesis of lactams and functionalized acyclic amines. Org. Chem. Front.,2021, 8, 5118-5123.

[7] Yan He,* Zhi Zheng, Qimeng Liu, Xinying Zhang, Xuesen Fan.* Solvent-regulated coupling of 2-alkynylbenzaldehydes with cyclic amines: selective synthesis of fused N-heterocycles and functionalized naphthalene derivatives. Org. Lett., 2020, 22, 9053-9058.

[8] Yan He,* Jintao Yang, Yajie Liu, Jiajie Qiao, Xinying Zhang, Xuesen Fan.* Synthesis of β-methyl sulfonylated N-heterocycles from saturated cyclic amines with the insertion of sulfur dioxide. J. Org. Chem., 2020, 85, 15600-15609.

[9] Yan He,* Zhi Zheng, Yajie Liu, Jiajie Qiao, Xinying Zhang, Xuesen Fan.* Selective synthesis of β-nitrated N-heterocycles and N-nitroso-2-alkoxyamine aldehydes from inactivated cyclic amines promoted by ^tBuONO and oxoammonium salt. Chem. Commun., 2019, 55,12372-12375.

[10] Yan He,* Zhi Zheng, Yajie Liu, Jiajie Qiao, Xinying Zhang, Xuesen Fan.* Selective cleavage and tunable functionalization of the C−C/C−N bonds of Narylpiperidines promoted by ^tBuONO. Org. Lett., 2019, 21,1676-1680.

[11] Yan He,* Tian Feng, Xuesen Fan.* Synthesis of functionalized indole-1-oxide derivatives via cascade reactions of allenynes and ^tBuONO. Org. Lett.,2019, 21, 3918-3922.

[12] Tian Feng, Yan He,* Xuesen Fan.* Synthesis of functionalized cyclobutane-fused naphthalene derivatives via cascade reactions of allenynes with tert-butyl nitrite. Adv. Synth. Catal., 2019, 361, 1271-1276.

[13] Fang Wang, Yan He,* Miaomiao Tian, Xinying Zhang, Xuesen Fan.* Synthesis of αformylated Nheterocycles and their 1,1-diacetates from inactivated cyclic amines involving an oxidative ring contraction. Org. Lett., 2018, 20, 864-867.

[14] Yan He,* Zhi Zheng, Qimeng Liu, Guixian Song, Nan Sun, Xinyuan Chai. Tunable synthesis of 2ene-1,4-diones, 4hydroxycyclopent-2-en-1-ones, and 2(furan-3-yl)acetamides via palladium-catalyzed cascade reactions of allenols.J. Org. Chem., 2018, 83, 12514-12526.

[15] Yan He,* Fang Wang, Xinying Zhang, Xuesen Fan.* C(sp³)–H dehydrogenation and C(sp²)–H alkoxycarbonylation of inactivated cyclic amines towards functionalized N-heterocycles. Chem. Commun., 2017, 53, 4002-4005.

[16] Yan He, Ningning Zhao, Liqi Qiu, Xinying Zhang,* Xuesen Fan.* Regio- and Chemoselective mono- and bisnitration of 8amino quinoline amides with Fe(NO₃)₃·9H₂O as promoter and nitro source. Org. Lett., 2016, 18,6054-6057.

[17] Yan He, Xinying Zhang*, and Xuesen Fan*. Synthesis of diversely substituted 2-(furan-3-yl)acetates from allenols through cascade carbonylations. Chem. Commun., 2015, 51, 16263-16266.

[18] Yan He, Xinying Zhang*, and Xuesen Fan*. One-pot cascade reactions of 1-arylpenta-3,4-dien-2-ones leading to 2-arylphenols and dibenzopyroanones. Chem. Commun., 2014, 50, 14968-14970.

[19] Yan He, Xinying Zhang and Xuesen Fan*. Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles. Chem. Commun., 2014, 50, 5641-5643.

[20] Yan He, Shenghai Guo, Xinying Zhang, and Xuesen Fan*. Zinc-mediated one-pot tandem reaction of nitriles with propargyl bromides: an easy access to 3-alkynylpyri dines and their applications. J. Org. Chem., 2014, 79, 10611.

[21] Xuesen Fan*, Yan He, Xinying Zhang, Jianji Wang. Sustainable and selective synthesis of 3,4-dihydro quinolizin-2-one and quinolizin-2-one derivatives via the reactions of penta-3,4-dien-2-ones. Green Chem., 2014, 16, 1393-1398.

[22] Yan He, Xinying Zhang*, Liangyan Cui, Jianji wang, and Xuesen Fan*. Catalyst-free synthesis of diversely substituted 6H-benzo[c]chromenes and 6H-benzo[c]-chromen-6-ones in aqueous media under MWI. Green Chem., 2012, 14, 3429-3435.

　授权发明专利

[1] 何艳，崔啸，牛佳文，张志远，范学森，张新迎，一种α-取代-β-胺氧基取代吗啉类化合物的合成方法，2024-09-06，中国，ZL202211339826.1.

[2]何艳，杜子翯，刘奇梦，范学森，张新迎，一种3-取代喹啉类化合物的合成方法，2024-1-26，中国，ZL202210965357.8.

[3]何艳，杜子翯，马靖涵，徐艳华，张新迎，范学森，一种N-芳基取代内酰胺类化合物的合成方法，2023-8-29，中国，ZL202110641292.7.

[4]何艳，张新迎，范学森，杨锦涛，一种3-甲磺酰基取代氮杂环类化合物的合成方法，2022-2-25，中国，ZL202011174018.5.

[5] 何艳，范学森，郑智，张新迎，一种多取代萘并氮杂环类化合物的合成方法，2022-2-8，中国，ZL202010931477.7.

[6] 何艳，范学森，张新迎，郑智，一种N-亚硝基-2-烷氨氧基醛类化合物的合成方法，2021-6-4，中国，ZL201910864065.3.

[7] 何艳，张新迎，王芳，范学森，一种α-二乙酰氧甲基取代含氮杂环类化合成方法，2020-1-31，中国，ZL201710903936.9.

[8] 何艳，范学森，张新迎，赵宁宁，邱丽琪，一种5-硝基-8-酰胺基喹啉类化合物的合成方法，2019-1-1，中国，ZL201610926193.2.